Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics.Here the authors engineer programmable RNA Deck Shoes sensors, DART VADARs, in which ADARs autocatalytically convert target hybridization into a translational output, thus amplifying editing by endoge
The majority of the human genome is transcribed, even though only 2% of transcripts encode proteins.Non-coding transcripts were originally dismissed as evolutionary junk or transcriptional noise, but with the development of whole genome technologies, these ncRNAs are emerging as molecules with vital roles in regulating gene expression.While shorter
Neutrophils are not only crucial immune cells for the neutralization of pathogens Bubble Bath during infections, but they are also key players in tissue repair and cancer.Several methods are available to investigate the in vivo role of neutrophils in these conditions, including the depletion of neutrophils with neutralizing antibodies against Ly6G,